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  • 台灣中文醫學期刊:

 

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早期乳癌乳房保留手術治療之新利器-部份乳房近接放射治療
台灣醫界2013, Vol.56, No.2 
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振興醫院放射腫瘤科王崇義

臺大醫院外科 * 高明見

 

  • 英文醫學期刊:

Breast Cancer

Publication SummaryReference
APBI: Retrospective study reporting clinical outcomes and a dosimetric comparison of Xoft versus Ir-192 following the treatment of early-stage breast cancer Dooley WC, Wurzer JC, Megahy M, et al. "Electronic Brachytherapy as Adjuvant Therapy for Early Stage Breast Cancer: A Retrospective Analysis." OncoTargets and Therapy 2011;4:13-20.
APBI: The EXIBT Registry initial interim analysis of one-year follow-up data demonstrating safety and efficacy using Xoft as an adjuvant radiation therapy for early-stage breast cancer Beitsch, PD, Patel RR, Lorenzetti JD, et al. "Post-surgical Treatment of Early-stage Breast Cancer With Electronic Brachytherapy: An Intersociety, Multicenter Brachytherapy Trial." OncoTargets and Therapy (3) 2010: 211–218.
APBI: Initial experience using Xoft eBx for the treatment of early-stage breast cancer; one-year follow-up is reported Mehta VK, Algan O, Greim K, et al. "Experience With an Electronic Brachytherapy Technique for Intracavitary Accelerated Partial Breast Irradiation." American Journal of Clinical Oncology (4:33) August 2010: 327–335.
APBI: RSNA preliminary report of 44-patient study results Mehta, VK. "Early Experience With an Electronic Brachytherapy Technique for Intracavitary Partial Breast Irradiation." RSNA 2009: Abstract.
APBI: ASCO Breast Cancer Symposium—Preliminary report of 44-patient study results Mehta V, Dooley W, Greim K, et al. "Early Experience With an Electronic Brachytherapy Technique for Intracavitary Partial Breast Irradiation." ASCO Breast Cancer Symposium 2008; Poster presentation December 2008.
Description of lumpectomy technique and reports similar outcomes to Iridium based balloon brachytherapy for APBI. Dooley WC, Algan O, Dowlatshahi K, et al. Surgical Perspectives from a Prospective Nonrandomized Multicenter Study of Breast Conserving Surgery and Adjuvant Electronic Brachytherapy for the Treatment of Breast Cancer. World J Surg Oncol 2011;9:30.
Follow-up paper with 1-2 year updates to the initial paper by Beitsch et al in OT&T 2010. Patel RR, Beitsch PD, Nichols TD, et al. Postsurgical Treatment of Early-stage Breast Cancer with Electronic Brachytherapy: Outcomes and Health-related Quality of Life at 1 Year. Am J Clin Oncol 2012 Jun 14.
IORT: Treatment methodology and clinical outcomes at one-year following the treatment of early-stage breast cancer, single fraction IORT are reported Ivanov O, Dickler A, Lum BYF, et al. "Twelve-Month Follow-up Results of a Trial Utilizing Axxent Electronic Brachytherapy to Deliver Intraoperative Radiation Therapy for Early-Stage Breast Cancer." Annals of Surgical Oncology 2011;18:453-458.
IORT: Detailed description of how to treat patients using the Xoft system intra-operatively at time of lumpectomy for the treatment of early-stage breast cancer Dickler A, Ivanov O, Francescatti D. "Intraoperative Radiation Therapy in the Treatment of Early-Stage Breast Cancer Utilizing Xoft Axxent Electronic Brachytherapy." World Journal of Surgical Oncology (7) 2009: 24.

Endometrial Cancer

Publication SummaryReference
eBx is acceptable for post operative vaginal brachytherapy and comparable with other methods with low toxicity rates Kamrava M, Chung MP, DeMarco J, et al. Electronic brachytherapy for postsurgical adjuvant vaginal cuff irradiation therapy in endometrial and cervical cancer: a retrospective study. Brachytherapy 2013;12:141-147.
Multi-center study reporting success of treatment delivery, safety and acute outcomes of patients treated with eBx for early-stage endometrial cancer post TAH-BSO Dickler A, Puthawala MY, Thropay JP, et al. "Prospective Multi-Center Trial Utilizing Electronic Brachytherapy for the Treatment of Endometrial Cancer." Radiation Oncology (5:67) 2010: 1–6.
Retrospective study evaluates feasibility and safety of Xoft system as a post-surgical adjuvant radiation therapy for the treatment of endometrial cancer Dooley WC, Thropay JP, Schreiber GJ, et al. "Use of Electronic Brachytherapy to Deliver Post-Surgical Adjuvant Radiation Therapy for Endometrial Cancer: A Retrospective Multicenter Study." OncoTargets and Therapy (3) 2010: 197–203.

Skin Cancer

Publication SummaryReference
Case report demonstrating successful treatment of a patient with squamous cell carcinoma in situ of the dorsal-distal finger. Arterbery VA, Watson AC. An electronic brachytherapy technique for treating squamous cell carcinoma in situ of the digit: a case report. BMC Research Notes 2013;6:147.
Clinical outcomes of patients with non-melanoma skin cancer treated with eBx: acute safety, efficacy, and cosmesis are reported Bhatnagar A, Loper A. "The Initial Experience of Electronic Brachytherapy for the Treatment of Non-melanoma Skin Cancer." Radiation Oncology (5:87) 2010: 1–8.
Treatment of 171 NMSC lesions in 122 patients was effective with no recurrences, good to excellent cosmesis, and acceptable toxicities at 1 year. Bhatnagar A. Nonmelanoma Skin Cancer Treated with Electronic Brachytherapy: Results at 1 year. Brachytherapy 2013;12:134-140.

Physics and Dosimetry

Publication SummaryReference
A comparison of the treatment plans for patients treated with eBx using the Axxent system as adjuvant therapy for early-stage breast cancer with treatment plans prepared from the same CT image sets using an Iridium-192 source Ahmad S, Johnson D, Hiatt JR, Still T, Furhang EE, Marsden D, Kearly F, Bernard DA, Holt RW. "Comparison of Tumor and Normal Tissue Dose for Accelerated Partial Breast Irradiation Using Electronic Brachytherapy eBx source and an Iridium-192 source." J Appl Clin Med Phys (11:4) 2010: 155–161.
Comprehensive calibration procedures for medical physicists for using the Xoft eBx system and skin applicators for non-melanoma skin cancer treatments Rong Y, Welsh JS. "Surface Applicator Calibration and Commissioning on the Xoft Electronic Brachytherapy for Non-melanoma Skin Cancer Treatment." Med Phys (37:10) 2010: 5509–5510.
Various balloon-insertion orientations to optimize skin surface dose are simulated Hepel JT, Hiatt JR, Cardarelli GA, et al. "Modeling Study for Optimization of Skin Dose for Partial Breast Irradiation Using Xoft Axxent Electronic Brachytherapy Applicator." Brachytherapy (9) 2010: 81–85.
Dosimetric comparison of eBx versus Ir-192 in APBI application Mille MM, Xu XG. "Comparison of Organ Doses For Patients Undergoing Balloon Brachytherapy of The Breast With HDR 192Ir or Electronic Sources Using Monte Carlo Simulations in a Heterogeneous Human Phantom." Medical Physics (37) 2010: 662–671.
Point-counterpoint discussion Sternick E, Todor D, Orton C. "Intensity Modulated Electronic Brachytherapy Will Soon Become The Brachytherapy Treatment of Choice For Irregularly Shaped Tumor Cavities or Those Closely Bounded by Critical Structures." Medical Physics (36) 2009: 681–683.
Electronic source will ultimately replace Ir-192 as the source for HDR Brachytherapy Holt RW, Thomadsen BR, Orton CG. "Mini-X-ray Tubes Will Ultimately Displace Ir-192 as The Radiation Source for High Dose-Rate Brachytherapy." Medical Physics (35) 2008: 815–817.
Measurements of X-ray spectra and half-value layers for the Axxent source, operating at 40 and 50 kV, are compared with Monte Carlo calculations using Geant4 Reniers B, Liu B, Rusch T, et al. "Calculation of RBE of a Low-Energy Electronic Brachytherapy Source." Physics in Medicine and Biology (53) 2008: 7125–7135.
Calculations and measurements of TG-43 source parameters Mahesh M, Detorie N, Holt R, et al. "Electronic Brachytherapy: Comparisons With External Beam and High Dose-Rate 192Ir Brachytherapy." Journal American College Radiology (5) 2008: 221–223.
Procedures used at Rhode Island Hospital to commission the Xoft system Hiatt JR, Cardarelli GA, Hepel J, et al. "A Commissioning Procedure for Breast Intracavitary Electronic Brachytherapy Systems." Journal of Applied Clinical Medical Physics (9) 2008: 58–68.
Dosimetric comparison Xoft versus Ir-192 Dickler A, Kirk MC, Seif M, et al. "A Dosimetric Comparison of Xoft Electronic Brachytherapy and Iridium-192 High Dose-Rate Brachytherapy." Brachytherapy (6) 2007: 164–168.
Dose volume characteristics of the 50kV source Smitt MC, Kirby R. "Dose Volume Characteristics of a 50kV Electronic Brachytherapy Source For Intracavitary Accelerated Partial Breast Irradiation." Brachytherapy (6) 2007: 207–211.
The Xoft system is described along with calculations and measurements of TG-43 source parameters Rivard M, Davis S, DeWerd L, et al. "Calculated and Measured Brachytherapy Dosimetry Parameters For The Xoft Axxent X-Ray Source: An Electronic Brachytherapy Source." Medical Physics (33) 2006: 4020–4032.
Measurements of X-ray spectra and half-value layers for the Axxent source, operating at 40 and 50 kV, are compared with Monte Carlo calculations using Geant4 Liu D, Poon E, Bazalova M, et al. "Spectroscopic Characterization of a Novel Electronic Brachytherapy System." Physics in Medicine and Biology (53) 2008: 61–78.